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Journal of Cystic Fibrosis : Official... May 2019The Dutch CF Foundation started to focus on scientific research thirteen years ago. The patient organization defined the patients perspective and unmet needs bottom-up,...
The Dutch CF Foundation started to focus on scientific research thirteen years ago. The patient organization defined the patients perspective and unmet needs bottom-up, and through a structured process. The patients research priorities were matched with the research priorities of Dutch basic scientists and clinicians. The Dutch patient organization facilitated the process, in which mutual dependency between patients, scientists and clinicians is the keyword. The, at that time initiated dialogue, maintained. Subsequently a research program called "HIT CF" was composed and executed over five years. HIT CF was financially supported mainly by the patient community and some other stakeholders.
Topics: Attitude of Health Personnel; Attitude to Health; Biomedical Research; Cystic Fibrosis; Humans; Needs Assessment; Netherlands; Patient Outcome Assessment; Patient Participation; Program Evaluation; Research; Translational Research, Biomedical
PubMed: 30926323
DOI: 10.1016/j.jcf.2019.03.008 -
Acta Reumatologica Portuguesa 2006
Topics: Biomedical Research; Europe; Portugal; Rheumatology; United States
PubMed: 17058356
DOI: No ID Found -
ELife Jun 2017Many biomedical research studies use captive animals to model human health and disease. However, a surprising number of studies show that the biological systems of...
Many biomedical research studies use captive animals to model human health and disease. However, a surprising number of studies show that the biological systems of animals living in standard laboratory housing are abnormal. To make animal studies more relevant to human health, research animals should live in the wild or be able to roam free in captive environments that offer a natural range of both positive and negative experiences. Recent technological advances now allow us to study freely roaming animals and we should make use of them.
Topics: Animals; Animals, Laboratory; Behavior, Animal; Biomedical Research; Disease Models, Animal; Humans
PubMed: 28661398
DOI: 10.7554/eLife.27438 -
ImmunoHorizons Jan 2022
Topics: Biomedical Research; Cultural Diversity; Humans; National Institute of General Medical Sciences (U.S.); United States; Workforce
PubMed: 35064028
DOI: 10.4049/immunohorizons.2100116 -
Journal of Acupuncture and Meridian... Dec 2013The purpose of this study was to trace the formative process of primo vascular system (PVS) research over the past decade and to describe the characteristics of the... (Review)
Review
Formative research on the primo vascular system and acceptance by the korean scientific community: the gap between creative basic science and practical convergence technology.
The purpose of this study was to trace the formative process of primo vascular system (PVS) research over the past decade and to describe the characteristics of the Korean scientific community. By publishing approximately 30 papers in journals ranking in the Science Citation Index (Expanded), the PVS research team actively convinced domestic and international scientists of the anatomical existence of the PVS and its possible application to Korean and Western medicine. In addition, by sharing the PVS observation technique, the team promoted the dissemination and further pursuit of the research. In 2012, however, PVS researchers performed smaller scale research without advancing to a higher level as compared to the early days. The main reasons were found to be the Korean Research and Development policy of supporting creative, small-scale basic research and applied research of Western scientific fields that promised potentially greater success on an extensive scale; the indifference concerning, and the disbelief in, the existence of a new circulatory system were shown by the Western medical community. In addition, the Oriental medical community was apathetic about working with the PVS team. Professors Kwang-Sup Soh and Byung-Cheon Lee were the prime movers of PVS research under difficult conditions. Spurred by their belief in the existence and significance of the PVS, they continued with their research despite insufficient experimental data. The Korean scientific community is not ready to promote the Korea-oriented creative field of the PVS team.
Topics: Acupuncture; Acupuncture Points; Biomedical Research; History, 21st Century; Humans; Medical Laboratory Personnel; Meridians; Republic of Korea; Workforce
PubMed: 24290796
DOI: 10.1016/j.jams.2013.04.001 -
International Journal of Medical... 2018Biomedical research has advanced swiftly in recent decades, largely due to progress in biotechnology. However, this rapid spread of new, and not always-fully understood,... (Review)
Review
Biomedical research has advanced swiftly in recent decades, largely due to progress in biotechnology. However, this rapid spread of new, and not always-fully understood, technology has also created a lot of false or irreproducible data and artifacts, which sometimes have led to erroneous conclusions. When describing various scientific issues, scientists have developed a habit of saying "on one hand… but on the other hand…", because discrepant data and conclusions have become omnipresent. One reason for this problematic situation is that we are not always thoughtful enough in study design, and sometimes lack enough philosophical contemplation. Another major reason is that we are too rushed in introducing new technology into our research without assimilating technical details. In this essay, we provide examples in different research realms to justify our points. To help readers test their own weaknesses, we raise questions on technical details of RNA reverse transcription, polymerase chain reactions, western blotting and immunohistochemical staining, as these methods are basic and are the base for other modern biotechnologies. Hopefully, after contemplation and reflection on these questions, readers will agree that we indeed know too little about these basic techniques, especially about the artifacts they may create, and thus many conclusions drawn from the studies using those ever-more-sophisticated techniques may be even more problematic.
Topics: Biomedical Research; Biotechnology; Humans
PubMed: 29511367
DOI: 10.7150/ijms.23215 -
EMBO Reports Jul 2012
Topics: Biomedical Research; Influenza A Virus, H5N1 Subtype
PubMed: 22934311
DOI: 10.1038/embor.2012.77 -
PLoS Computational Biology Oct 2020Contributing to broader impacts is an important aspect of scientific research. Engaging practicing K-12 teachers as part of a research project can be an effective...
Contributing to broader impacts is an important aspect of scientific research. Engaging practicing K-12 teachers as part of a research project can be an effective approach for addressing broader impacts requirements of grants, while also advancing researcher and teacher professional growth. Our focus is on leveraging teachers' professional expertise to develop science education materials grounded in emerging scientific research. In this paper, we describe ten simple rules for planning, implementing, and evaluating teacher engagement to support the broader impact goals of your research project. These collaborations can lead to the development of instructional materials or activities for students in the classroom or provide science research opportunities for teachers. We share our successes and lessons learned while collaborating with high school biology teachers to create technology-based, instructional materials developed from basic biological research. The rules we describe are applicable across teacher partnerships at any grade level in that they emphasize eliciting and respecting teachers' professionalism and expertise.
Topics: Biomedical Research; Cooperative Behavior; Humans; Research Personnel; School Teachers; Science
PubMed: 33001970
DOI: 10.1371/journal.pcbi.1008225 -
Cell Mar 2016Assessing the real-world impact of biomedical research is notoriously difficult. Here, we present the framework for building a prospective science-centered information...
Assessing the real-world impact of biomedical research is notoriously difficult. Here, we present the framework for building a prospective science-centered information system from scratch that has been afforded by the Sidra Medical and Research Center in Qatar. This experiment is part of the global conversation on maximizing returns on research investment.
Topics: Biomedical Research; Human Genome Project; Humans; Information Systems; Knowledge Bases; Qatar; Research Design
PubMed: 27015300
DOI: 10.1016/j.cell.2016.03.004 -
Journal of Cellular and Molecular... Feb 2017
Topics: Biomedical Research; Cell Biology; Editorial Policies; Forecasting; Humans; Journal Impact Factor; Molecular Biology; Molecular Medicine; Periodicals as Topic
PubMed: 28121074
DOI: 10.1111/jcmm.13075